Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3780424..3781081 Replicon chromosome
Accession NZ_CP115874
Organism Enterobacter hormaechei subsp. steigerwaltii strain WYTS.MG41

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag PBS85_RS17785 Protein ID WP_017382887.1
Coordinates 3780424..3780834 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PBS85_RS17790 Protein ID WP_003863437.1
Coordinates 3780815..3781081 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBS85_RS17765 (PBS85_17765) 3776422..3778155 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
PBS85_RS17770 (PBS85_17770) 3778161..3778874 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PBS85_RS17775 (PBS85_17775) 3778903..3779799 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PBS85_RS17780 (PBS85_17780) 3779901..3780422 + 522 WP_015571793.1 flavodoxin FldB -
PBS85_RS17785 (PBS85_17785) 3780424..3780834 - 411 WP_017382887.1 protein YgfX Toxin
PBS85_RS17790 (PBS85_17790) 3780815..3781081 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PBS85_RS17795 (PBS85_17795) 3781376..3782356 + 981 WP_032669268.1 tRNA-modifying protein YgfZ -
PBS85_RS17800 (PBS85_17800) 3782468..3783127 - 660 WP_003863433.1 hemolysin III family protein -
PBS85_RS17805 (PBS85_17805) 3783394..3784125 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
PBS85_RS17810 (PBS85_17810) 3784242..3785675 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T267454 WP_017382887.1 NZ_CP115874:c3780834-3780424 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT267454 WP_003863437.1 NZ_CP115874:c3781081-3780815 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References