Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2312700..2313678 Replicon chromosome
Accession NZ_CP115856
Organism Bacillus cereus strain PL22-16A

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag PFY08_RS11970 Protein ID WP_000624977.1
Coordinates 2312700..2313437 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID M1PKC2
Locus tag PFY08_RS11975 Protein ID WP_000237819.1
Coordinates 2313550..2313678 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFY08_RS11945 (PFY08_11945) 2308313..2308720 + 408 WP_000072495.1 VOC family protein -
PFY08_RS11950 (PFY08_11950) 2308744..2309124 + 381 Protein_2270 SAM-dependent methyltransferase -
PFY08_RS11955 (PFY08_11955) 2309282..2310967 - 1686 WP_002041140.1 alpha-keto acid decarboxylase family protein -
PFY08_RS11960 (PFY08_11960) 2311075..2311557 + 483 WP_000191885.1 MarR family winged helix-turn-helix transcriptional regulator -
PFY08_RS11965 (PFY08_11965) 2311724..2312461 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PFY08_RS11970 (PFY08_11970) 2312700..2313437 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PFY08_RS11975 (PFY08_11975) 2313550..2313678 + 129 WP_000237819.1 hypothetical protein Antitoxin
PFY08_RS11980 (PFY08_11980) 2313751..2313927 + 177 WP_000852629.1 stage II sporulation protein SB -
PFY08_RS11985 (PFY08_11985) 2313943..2314332 - 390 WP_000713869.1 YxeA family protein -
PFY08_RS11990 (PFY08_11990) 2314544..2316013 + 1470 WP_000287546.1 beta-Ala-His dipeptidase -
PFY08_RS11995 (PFY08_11995) 2316259..2317068 + 810 WP_000664544.1 papain-like cysteine protease family protein -
PFY08_RS12000 (PFY08_12000) 2317094..2317696 + 603 WP_000517259.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T267440 WP_000624977.1 NZ_CP115856:2312700-2313437 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4953.36 Da        Isoelectric Point: 3.9798

>AT267440 WP_000237819.1 NZ_CP115856:2313550-2313678 [Bacillus cereus]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB M1PKC2

References