Detailed information of TA system TA026744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1024788..1025306
• Replicon: chromosome
• Accession: NC_017353
• Organism: Staphylococcus lugdunensis N920143

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: SLUG_RS04795
• Protein ID: WP_002478973.1
• Coordinates: 1025094..1025306 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A853V130
• Locus tag: SLUG_RS04790
• Protein ID: WP_002492098.1
• Coordinates: 1024788..1025081 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLUG_RS04770	1020388..1021026	+	639	WP_002478970.1	thiamine phosphate synthase	-
SLUG_RS04775	1021116..1021991	+	876	WP_002461212.1	membrane protein insertase YidC	-
SLUG_RS04780	1022375..1023016	-	642	WP_002478971.1	HD domain-containing protein	-
SLUG_RS04785	1023138..1024622	-	1485	WP_002478972.1	cardiolipin synthase	-
SLUG_RS04790	1024788..1025081	+	294	WP_002492098.1	copper-sensing transcriptional repressor CsoR	Antitoxin
SLUG_RS04795	1025094..1025306	+	213	WP_002478973.1	heavy-metal-associated domain-containing protein	Toxin
SLUG_RS12695	1025397..1025534	+	138	WP_002461206.1	hypothetical protein	-
SLUG_RS04800	1025948..1027138	-	1191	WP_002461205.1	rod shape-determining protein RodA	-
SLUG_RS04805	1027494..1028564	+	1071	WP_002461204.1	D-alanine--D-alanine ligase	-
SLUG_RS04810	1028582..1029940	+	1359	WP_002478974.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-90)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8070.03 Da
• Isoelectric Point: 3.9947

>T26744 WP_002478973.1 NC_017353:1025094-1025306 [Staphylococcus lugdunensis N920143]
VEKRLIYITNVTSEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDAGYHAIDDL

Nucleotide

• Length: 213 bp

>T26744 NC_017353:1025094-1025306 [Staphylococcus lugdunensis N920143]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11177.85 Da
• Isoelectric Point: 6.6367

>AT26744 WP_002492098.1 NC_017353:1024788-1025081 [Staphylococcus lugdunensis N920143]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Nucleotide

• Length: 294 bp

>AT26744 NC_017353:1024788-1025081 [Staphylococcus lugdunensis N920143]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAAATGCTAAAAGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V130