Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240397..241039 Replicon chromosome
Accession NZ_CP115856
Organism Bacillus cereus strain PL22-16A

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag PFY08_RS01370 Protein ID WP_000635963.1
Coordinates 240689..241039 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PFY08_RS01365 Protein ID WP_000004570.1
Coordinates 240397..240684 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFY08_RS01340 (PFY08_01340) 235714..236676 + 963 WP_000961166.1 UV DNA damage repair endonuclease UvsE -
PFY08_RS01345 (PFY08_01345) 236669..237241 - 573 WP_000586917.1 rhomboid family intramembrane serine protease -
PFY08_RS01350 (PFY08_01350) 237335..237694 + 360 WP_000583416.1 holo-ACP synthase -
PFY08_RS01355 (PFY08_01355) 237851..238801 + 951 WP_071740808.1 outer membrane lipoprotein carrier protein LolA -
PFY08_RS01360 (PFY08_01360) 238919..240088 + 1170 WP_000390615.1 alanine racemase -
PFY08_RS01365 (PFY08_01365) 240397..240684 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PFY08_RS01370 (PFY08_01370) 240689..241039 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PFY08_RS01375 (PFY08_01375) 241107..243275 + 2169 WP_000426242.1 Tex family protein -
PFY08_RS01380 (PFY08_01380) 243333..243449 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PFY08_RS01385 (PFY08_01385) 243645..244103 + 459 WP_071740807.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T267439 WP_000635963.1 NZ_CP115856:240689-241039 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT267439 WP_000004570.1 NZ_CP115856:240397-240684 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References