Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 398364..399154 Replicon plasmid pAtG3_79a
Accession NZ_CP115843
Organism Agrobacterium fabacearum strain G3/79

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1S7NFF1
Locus tag G6L97_RS25130 Protein ID WP_019565755.1
Coordinates 398657..399154 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1S7NER6
Locus tag G6L97_RS25125 Protein ID WP_019565754.1
Coordinates 398364..398660 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L97_RS25105 (G6L97_25105) 393733..395457 + 1725 WP_162633664.1 ABC transporter ATP-binding protein -
G6L97_RS25110 (G6L97_25110) 395502..396689 + 1188 WP_174004093.1 galactarate dehydratase -
G6L97_RS25115 (G6L97_25115) 396676..397542 + 867 WP_174004095.1 aldose 1-epimerase -
G6L97_RS25120 (G6L97_25120) 397752..398182 + 431 Protein_388 DDE-type integrase/transposase/recombinase -
G6L97_RS25125 (G6L97_25125) 398364..398660 + 297 WP_019565754.1 DUF1778 domain-containing protein Antitoxin
G6L97_RS25130 (G6L97_25130) 398657..399154 + 498 WP_019565755.1 GNAT family N-acetyltransferase Toxin
G6L97_RS25135 (G6L97_25135) 399433..400098 - 666 WP_081308998.1 GNAT family N-acetyltransferase -
G6L97_RS25140 (G6L97_25140) 400064..401224 - 1161 WP_174004096.1 Gfo/Idh/MocA family oxidoreductase -
G6L97_RS25145 (G6L97_25145) 401256..402506 - 1251 WP_111783769.1 ROK family protein -
G6L97_RS25150 (G6L97_25150) 402719..403678 + 960 WP_111783770.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..632660 632660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(16-90)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17725.27 Da        Isoelectric Point: 6.8629

>T267437 WP_019565755.1 NZ_CP115843:398657-399154 [Agrobacterium fabacearum]
VTLSAPVPLADHHELAEFNSGVPELDDWLRRRARANQAGGASRTFVVCDESRVIAYYALASGSVKPPEVPGRFRRNMPDP
IPVAVLGRLAIDQSCQGRGIGRALVRDAGLRLLNAAEVLGIRGVLVHAISDDARAFYEAVGFLSSPSDPMMLMVGLHDLN
NALNT

Download         Length: 498 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11022.59 Da        Isoelectric Point: 7.0159

>AT267437 WP_019565754.1 NZ_CP115843:398364-398660 [Agrobacterium fabacearum]
MPTSHTGKSPDASVPLNMRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRTIVTVSPEIYAEYLARLDAPAQ
PNERLKRTMSTKAPWDEA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7NFF1

Antitoxin

Source ID Structure
AlphaFold DB A0A1S7NER6

References