Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2128575..2130085 Replicon chromosome
Accession NZ_CP115842
Organism Agrobacterium fabacearum strain G3/79

Toxin (Protein)


Gene name HipA1 Uniprot ID F0LBK0
Locus tag G6L97_RS23125 Protein ID WP_013762466.1
Coordinates 2128844..2130085 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID F0LBJ9
Locus tag G6L97_RS23120 Protein ID WP_013762465.1
Coordinates 2128575..2128847 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L97_RS23075 (G6L97_23075) 2123661..2124062 - 402 WP_013762456.1 hypothetical protein -
G6L97_RS23080 (G6L97_23080) 2124101..2124316 - 216 WP_019567388.1 hypothetical protein -
G6L97_RS23085 (G6L97_23085) 2124657..2124779 + 123 WP_003518941.1 hypothetical protein -
G6L97_RS23090 (G6L97_23090) 2124980..2125639 - 660 WP_013762458.1 porin family protein -
G6L97_RS23095 (G6L97_23095) 2125847..2126230 - 384 WP_025594780.1 ester cyclase -
G6L97_RS23100 (G6L97_23100) 2126301..2126921 - 621 WP_025594779.1 histidine phosphatase family protein -
G6L97_RS23105 (G6L97_23105) 2126899..2127468 - 570 Protein_1864 AAA family ATPase -
G6L97_RS23110 (G6L97_23110) 2127581..2127709 - 129 WP_003518932.1 hypothetical protein -
G6L97_RS23115 (G6L97_23115) 2127833..2128153 - 321 WP_013762464.1 hypothetical protein -
G6L97_RS23120 (G6L97_23120) 2128575..2128847 + 273 WP_013762465.1 helix-turn-helix domain-containing protein Antitoxin
G6L97_RS23125 (G6L97_23125) 2128844..2130085 + 1242 WP_013762466.1 type II toxin-antitoxin system HipA family toxin Toxin
G6L97_RS23130 (G6L97_23130) 2130075..2130215 + 141 WP_156390030.1 hypothetical protein -
G6L97_RS23135 (G6L97_23135) 2131238..2132332 + 1095 WP_013762468.1 helix-turn-helix transcriptional regulator -
G6L97_RS23140 (G6L97_23140) 2132966..2133091 + 126 WP_256372464.1 hypothetical protein -
G6L97_RS23145 (G6L97_23145) 2133704..2133976 + 273 WP_029658823.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6L97_RS23150 (G6L97_23150) 2133963..2134085 + 123 Protein_1873 plasmid maintenance toxin (PemK-like) -
G6L97_RS23155 (G6L97_23155) 2134257..2134466 + 210 WP_174003888.1 hypothetical protein -
G6L97_RS23160 (G6L97_23160) 2134662..2134934 + 273 WP_236735824.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45352.22 Da        Isoelectric Point: 7.8873

>T267434 WP_013762466.1 NZ_CP115842:2128844-2130085 [Agrobacterium fabacearum]
MTTIYYETLPVAHLTFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRFKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLRPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVDGNGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLEAAEATIGVAGKRRYLLVKRYDRFTDPQGEIRRLHQEDLCQLTGC
FPSQKYERSSTGRGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RQVDQSLPQGIFGRFHAPDLRRADWQALADDIGLSGASTLKRVGELAKLVSVACDEVAPYIVALSSDPTRILERITHSVQ
KRCRRIQEQMHDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.07 Da        Isoelectric Point: 6.2834

>AT267434 WP_013762465.1 NZ_CP115842:2128575-2128847 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQVASDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0LBK0

Antitoxin

Source ID Structure
AlphaFold DB F0LBJ9

References