Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4889079..4890760 Replicon chromosome
Accession NZ_CP115837
Organism Klebsiella pneumoniae strain MRSN22265

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag KFB76_RS24025 Protein ID WP_019724882.1
Coordinates 4889079..4889996 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag KFB76_RS24030 Protein ID WP_004177809.1
Coordinates 4890002..4890760 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFB76_RS24005 (KFB76_024000) 4884385..4885905 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
KFB76_RS24010 (KFB76_024005) 4885902..4886900 + 999 WP_002885172.1 ribose ABC transporter permease -
KFB76_RS24015 (KFB76_024010) 4886931..4887872 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
KFB76_RS24020 (KFB76_024015) 4887947..4888954 + 1008 WP_015959270.1 carbohydrate kinase family protein -
KFB76_RS24025 (KFB76_024020) 4889079..4889996 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KFB76_RS24030 (KFB76_024025) 4890002..4890760 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KFB76_RS24035 (KFB76_024030) 4890846..4891574 - 729 WP_002885152.1 response regulator transcription factor -
KFB76_RS24040 (KFB76_024035) 4891847..4893994 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
KFB76_RS24045 (KFB76_024040) 4894224..4894910 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T267431 WP_019724882.1 NZ_CP115837:c4889996-4889079 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT267431 WP_004177809.1 NZ_CP115837:c4890760-4890002 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References