26743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 890113..890915 Replicon chromosome
Accession NC_017353
Organism Staphylococcus lugdunensis N920143

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag SLUG_RS04035 Protein ID WP_014533241.1
Coordinates 890113..890577 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SLUG_RS04040 Protein ID WP_014533242.1
Coordinates 890592..890915 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLUG_RS04005 885367..886341 + 975 WP_002460008.1 tagatose-bisphosphate aldolase -
SLUG_RS04010 886361..886672 + 312 WP_002460006.1 PTS lactose transporter subunit IIA -
SLUG_RS04015 886678..887559 + 882 Protein_805 PTS transporter subunit EIIC -
SLUG_RS04020 887581..888963 - 1383 WP_014533238.1 recombinase family protein -
SLUG_RS04025 889021..889569 - 549 WP_014533239.1 hypothetical protein -
SLUG_RS04030 889591..890100 - 510 WP_014533240.1 hypothetical protein -
SLUG_RS04035 890113..890577 - 465 WP_014533241.1 ImmA/IrrE family metallo-endopeptidase Toxin
SLUG_RS04040 890592..890915 - 324 WP_014533242.1 helix-turn-helix domain-containing protein Antitoxin
SLUG_RS04045 891081..891329 + 249 WP_044019727.1 helix-turn-helix domain-containing protein -
SLUG_RS04050 891344..892225 + 882 WP_014533244.1 DUF3102 domain-containing protein -
SLUG_RS04055 892238..892732 + 495 WP_014533245.1 ORF6C domain-containing protein -
SLUG_RS12905 892771..892932 + 162 WP_014533246.1 hypothetical protein -
SLUG_RS04065 892938..893201 - 264 WP_014533247.1 CRISPR-associated protein Cas2 -
SLUG_RS04070 893259..894014 + 756 WP_014533248.1 phage antirepressor KilAC domain-containing protein -
SLUG_RS12680 894030..894173 + 144 WP_002478861.1 hypothetical protein -
SLUG_RS04075 894183..894785 - 603 WP_014533249.1 hypothetical protein -
SLUG_RS04080 895013..895192 + 180 WP_002478864.1 hypothetical protein -
SLUG_RS04085 895261..895746 + 486 WP_002478865.1 siphovirus Gp157 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 887581..929661 42080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18094.58 Da        Isoelectric Point: 6.0777

>T26743 WP_014533241.1 NC_017353:c890577-890113 [Staphylococcus lugdunensis N920143]
MGLYEEMLAKHNYIEIRETDVMPPNLYGVWLGDLILIKRDISDKLKLEVLSEELAHHRLSYGDITDISNFNNRKFENHAR
RYAKEKLVSLDGIVEAFKQGIHNLYELANFFEVSEGFALESLAHYKQKYGVSKQHGDHLITFEPLRVFKYENFE

Download         Length: 465 bp

>T26743 NC_017353:c890577-890113 [Staphylococcus lugdunensis N920143]
ATGGGGTTATACGAAGAGATGTTAGCAAAGCATAACTATATAGAAATAAGGGAAACTGATGTTATGCCACCCAACCTTTA
CGGGGTGTGGTTGGGTGATTTAATTTTAATTAAAAGGGATATTTCGGACAAACTCAAACTAGAAGTTTTATCAGAAGAGT
TGGCTCATCATCGTCTATCTTATGGCGATATTACAGATATTTCAAATTTTAATAATAGGAAATTTGAAAACCATGCTAGA
AGATACGCAAAAGAAAAGTTGGTTTCATTAGATGGCATCGTAGAAGCTTTTAAGCAAGGAATACATAATTTGTATGAACT
TGCTAATTTTTTTGAGGTTTCAGAAGGTTTTGCACTAGAAAGTTTGGCGCATTATAAACAGAAATATGGTGTTTCCAAAC
AACACGGTGATCACTTAATAACATTTGAGCCTTTACGTGTATTTAAATATGAAAATTTTGAATAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12533.18 Da        Isoelectric Point: 7.2050

>AT26743 WP_014533242.1 NC_017353:c890915-890592 [Staphylococcus lugdunensis N920143]
MRTSSEIGKLIKQLRKENNVSLTDFAKKIGVNKSTLSRYENGSRKIPMEDIAEIANILNVTPERLLLKKYQSENENDHRA
AHLEQELTEEEWQEVLDYADFIRSKRK

Download         Length: 324 bp

>AT26743 NC_017353:c890915-890592 [Staphylococcus lugdunensis N920143]
ATGAGAACTTCATCAGAAATCGGCAAGTTAATTAAACAATTACGCAAAGAAAATAATGTAAGTTTAACTGACTTTGCTAA
AAAAATAGGAGTTAATAAATCTACTTTATCAAGATATGAAAACGGCAGTAGAAAAATTCCTATGGAAGATATTGCAGAAA
TAGCCAACATTTTAAATGTAACTCCAGAACGTTTATTACTTAAGAAATATCAATCTGAAAATGAAAATGATCATCGCGCG
GCGCACTTAGAACAAGAGTTAACCGAAGAAGAATGGCAAGAAGTTTTGGATTACGCAGATTTTATAAGAAGTAAAAGAAA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References