Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802585..803242 Replicon chromosome
Accession NZ_CP115837
Organism Klebsiella pneumoniae strain MRSN22265

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KFB76_RS03985 Protein ID WP_002916310.1
Coordinates 802832..803242 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KFB76_RS03980 Protein ID WP_002916312.1
Coordinates 802585..802851 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFB76_RS03955 (KFB76_003955) 797741..799174 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KFB76_RS03960 (KFB76_003960) 799293..800021 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KFB76_RS03965 (KFB76_003965) 800071..800382 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KFB76_RS03970 (KFB76_003970) 800546..801205 + 660 WP_002916317.1 hemolysin III family protein -
KFB76_RS03975 (KFB76_003975) 801356..802339 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KFB76_RS03980 (KFB76_003980) 802585..802851 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KFB76_RS03985 (KFB76_003985) 802832..803242 + 411 WP_002916310.1 protein YgfX Toxin
KFB76_RS03990 (KFB76_003990) 803249..803770 - 522 WP_002916308.1 flavodoxin FldB -
KFB76_RS03995 (KFB76_003995) 803871..804767 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KFB76_RS04000 (KFB76_004000) 804790..805503 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFB76_RS04005 (KFB76_004005) 805509..807242 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T267418 WP_002916310.1 NZ_CP115837:802832-803242 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT267418 WP_002916312.1 NZ_CP115837:802585-802851 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References