Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 32101..32636 Replicon plasmid pL4FAA5_2
Accession NZ_CP115833
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PGO70_RS26375 Protein ID WP_016531292.1
Coordinates 32101..32388 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W9BAK2
Locus tag PGO70_RS26380 Protein ID WP_016531291.1
Coordinates 32385..32636 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS26355 (PGO70_26350) 27900..29120 - 1221 WP_032446666.1 ISL3-like element ISKox3 family transposase -
PGO70_RS26360 (PGO70_26355) 29281..29757 + 477 WP_016529487.1 hypothetical protein -
PGO70_RS26365 (PGO70_26360) 30014..30301 - 288 WP_016529486.1 hypothetical protein -
PGO70_RS26370 (PGO70_26365) 30391..31053 - 663 WP_016529485.1 division plane positioning ATPase MipZ -
PGO70_RS26375 (PGO70_26370) 32101..32388 - 288 WP_016531292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGO70_RS26380 (PGO70_26375) 32385..32636 - 252 WP_016531291.1 toxin-antitoxin stability system antitoxin protein StbD Antitoxin
PGO70_RS26385 (PGO70_26380) 32732..34003 - 1272 WP_046041953.1 Y-family DNA polymerase -
PGO70_RS26390 (PGO70_26385) 34003..34497 - 495 WP_109234271.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
PGO70_RS26395 (PGO70_26390) 34483..35562 + 1080 WP_016531016.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - clbI / basG 1..95204 95204
- flank IS/Tn - - 27900..29120 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.16 Da        Isoelectric Point: 10.4373

>T267415 WP_016531292.1 NZ_CP115833:c32388-32101 [Klebsiella pneumoniae]
MTYTVKFREDALKEWNKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDNQLIIAIVAVGK
RERSDVYTLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.68 Da        Isoelectric Point: 4.2257

>AT267415 WP_016531291.1 NZ_CP115833:c32636-32385 [Klebsiella pneumoniae]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELIKLVAERSNQPLFDMDLE
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W9BAK2

References