Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4734427..4734943 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PGO70_RS22675 Protein ID WP_032446557.1
Coordinates 4734427..4734711 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PGO70_RS22680 Protein ID WP_002886901.1
Coordinates 4734701..4734943 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS22650 (4729823) 4729823..4730086 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
PGO70_RS22655 (4730216) 4730216..4730389 + 174 WP_002886906.1 hypothetical protein -
PGO70_RS22660 (4730392) 4730392..4731135 + 744 WP_032446555.1 MurR/RpiR family transcriptional regulator -
PGO70_RS22665 (4731492) 4731492..4733630 + 2139 WP_032446556.1 anaerobic ribonucleoside-triphosphate reductase -
PGO70_RS22670 (4733959) 4733959..4734423 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PGO70_RS22675 (4734427) 4734427..4734711 - 285 WP_032446557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGO70_RS22680 (4734701) 4734701..4734943 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PGO70_RS22685 (4735021) 4735021..4736931 - 1911 WP_004152270.1 PRD domain-containing protein -
PGO70_RS22690 (4736954) 4736954..4738108 - 1155 WP_002886900.1 lactonase family protein -
PGO70_RS22695 (4738175) 4738175..4738915 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11110.98 Da        Isoelectric Point: 10.3787

>T267409 WP_032446557.1 NZ_CP115831:c4734711-4734427 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHLANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT267409 WP_002886901.1 NZ_CP115831:c4734943-4734701 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References