Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2686956..2688544 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PGO70_RS12910 Protein ID WP_019705665.1
Coordinates 2686956..2688278 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PGO70_RS12915 Protein ID WP_002904790.1
Coordinates 2688278..2688544 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS12895 (2682012) 2682012..2684513 + 2502 WP_032446039.1 fimbria/pilus outer membrane usher protein -
PGO70_RS12900 (2684501) 2684501..2685505 + 1005 WP_032446038.1 fimbrial protein -
PGO70_RS12905 (2685647) 2685647..2686939 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PGO70_RS12910 (2686956) 2686956..2688278 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
PGO70_RS12915 (2688278) 2688278..2688544 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PGO70_RS12920 (2688809) 2688809..2689135 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PGO70_RS12925 (2689132) 2689132..2689632 - 501 WP_032446037.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PGO70_RS12930 (2689610) 2689610..2690989 - 1380 WP_032446036.1 nucleobase:cation symporter-2 family protein -
PGO70_RS12935 (2691335) 2691335..2692489 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PGO70_RS12940 (2692470) 2692470..2693393 - 924 WP_032436334.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T267405 WP_019705665.1 NZ_CP115831:c2688278-2686956 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT267405 WP_002904790.1 NZ_CP115831:c2688544-2688278 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References