Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780599..781256 Replicon chromosome
Accession NZ_CP115831
Organism Klebsiella pneumoniae strain L4-FAA5

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PGO70_RS03905 Protein ID WP_002916310.1
Coordinates 780846..781256 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PGO70_RS03900 Protein ID WP_002916312.1
Coordinates 780599..780865 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGO70_RS03875 (775755) 775755..777188 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
PGO70_RS03880 (777307) 777307..778035 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PGO70_RS03885 (778085) 778085..778396 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PGO70_RS03890 (778560) 778560..779219 + 660 WP_002916317.1 hemolysin III family protein -
PGO70_RS03895 (779370) 779370..780353 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
PGO70_RS03900 (780599) 780599..780865 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PGO70_RS03905 (780846) 780846..781256 + 411 WP_002916310.1 protein YgfX Toxin
PGO70_RS03910 (781263) 781263..781784 - 522 WP_004144730.1 flavodoxin FldB -
PGO70_RS03915 (781885) 781885..782781 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PGO70_RS03920 (782804) 782804..783517 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PGO70_RS03925 (783523) 783523..785256 + 1734 WP_032445465.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T267400 WP_002916310.1 NZ_CP115831:780846-781256 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT267400 WP_002916312.1 NZ_CP115831:780599-780865 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References