267385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1093494..1093987 Replicon chromosome
Accession NZ_CP115812
Organism Enterococcus faecium strain DMEA09

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag PAN98_RS05380 Protein ID WP_002329323.1
Coordinates 1093721..1093987 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag PAN98_RS05375 Protein ID WP_002329324.1
Coordinates 1093494..1093724 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAN98_RS05345 (PAN98_05345) 1088498..1089265 + 768 WP_271104644.1 MurR/RpiR family transcriptional regulator -
PAN98_RS05350 (PAN98_05350) 1089266..1089709 + 444 WP_002329330.1 hypothetical protein -
PAN98_RS05355 (PAN98_05355) 1089881..1090509 - 629 Protein_1060 glutamine amidotransferase -
PAN98_RS05360 (PAN98_05360) 1091156..1092115 - 960 WP_002293280.1 IS30-like element IS6770 family transposase -
PAN98_RS05365 (PAN98_05365) 1092365..1092670 + 306 WP_002329327.1 hypothetical protein -
PAN98_RS05370 (PAN98_05370) 1092683..1093018 + 336 WP_002329326.1 hypothetical protein -
PAN98_RS05375 (PAN98_05375) 1093494..1093724 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
PAN98_RS05380 (PAN98_05380) 1093721..1093987 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAN98_RS05385 (PAN98_05385) 1094239..1094466 + 228 WP_002329322.1 hypothetical protein -
PAN98_RS05390 (PAN98_05390) 1094482..1095648 + 1167 WP_002329321.1 radical SAM family heme chaperone HemW -
PAN98_RS05395 (PAN98_05395) 1095881..1096924 + 1044 WP_002329320.1 heat-inducible transcriptional repressor HrcA -
PAN98_RS05400 (PAN98_05400) 1097018..1097581 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1091156..1092115 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T267385 WP_002329323.1 NZ_CP115812:1093721-1093987 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT267385 WP_002329324.1 NZ_CP115812:1093494-1093724 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References