267381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 193397..194427 Replicon plasmid p1
Accession NZ_CP115780
Organism Paracoccus aerodenitrificans strain SCSIO 75817

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PAE61_RS00945 Protein ID WP_271112101.1
Coordinates 193397..193966 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A0J5Q733
Locus tag PAE61_RS00950 Protein ID WP_047997849.1
Coordinates 193963..194427 (-) Length 155 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE61_RS00915 (PAE61_00925) 189059..189751 + 693 WP_271112098.1 MBL fold metallo-hydrolase -
PAE61_RS00920 (PAE61_00930) 189748..190437 + 690 WP_271112099.1 GntR family transcriptional regulator -
PAE61_RS00925 (PAE61_00935) 190434..191630 + 1197 WP_271112100.1 L-2-hydroxyglutarate oxidase -
PAE61_RS00930 (PAE61_00940) 191991..192713 + 723 Protein_185 zinc-binding dehydrogenase -
PAE61_RS00935 (PAE61_00945) 192718..192903 + 186 Protein_186 alpha/beta hydrolase -
PAE61_RS00940 (PAE61_00950) 193073..193195 + 123 Protein_187 cyclophilin-like fold protein -
PAE61_RS00945 (PAE61_00955) 193397..193966 - 570 WP_271112101.1 PIN domain-containing protein Toxin
PAE61_RS00950 (PAE61_00960) 193963..194427 - 465 WP_047997849.1 helix-turn-helix domain-containing protein Antitoxin
PAE61_RS00955 (PAE61_00965) 194625..194744 + 120 Protein_190 IS110 family transposase -
PAE61_RS00960 (PAE61_00970) 194907..195182 - 276 WP_271112102.1 hypothetical protein -
PAE61_RS00965 (PAE61_00975) 195298..196365 - 1068 WP_271112103.1 hypothetical protein -
PAE61_RS00970 (PAE61_00980) 196594..197478 + 885 WP_028288628.1 recombinase family protein -
PAE61_RS00975 (PAE61_00985) 197557..197952 - 396 WP_028288627.1 PIN domain-containing protein -
PAE61_RS00980 (PAE61_00990) 197942..198169 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..198273 198273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-113)

Antitoxin

(81-126)


Sequences


Toxin        


Download         Length: 190 a.a.        Molecular weight: 21279.53 Da        Isoelectric Point: 5.0480

>T267381 WP_271112101.1 NZ_CP115780:c193966-193397 [Paracoccus aerodenitrificans]
MSQYTVLFDANVLYPAPMRDALMQLAVTDLFKAKWTADIHREWIDALLRNEPHRERAALERTRDLMDRATRDCLVTGYEA
LVPALILPDPDDRHVLAAAIVGRCDAIVTQNMKDFPPEALVPFGIETQHPDDFFRNQLSLAPGLVCSALRKVRARLKNPP
KSVDEYLSILTQQGLVATVADLEQFADLL

Download         Length: 570 bp


Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16732.29 Da        Isoelectric Point: 6.1002

>AT267381 WP_047997849.1 NZ_CP115780:c194427-193963 [Paracoccus aerodenitrificans]
MNMLAHRHLPPTPQDAAIARVSGQALSRFAAARGPLKLRVTDAEQMEPIELPAGAVALLMEILEAMAAGRGVTIIPENAE
LSTVQAAEVLNVSRPFLIKLLEDGSIPHRKVGKHRRVRMEDVMSYKAAIDNEREAVLDQLAADAQDQDMGYGSK

Download         Length: 465 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0J5Q733

References