Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 73113..73740 Replicon plasmid p1
Accession NZ_CP115769
Organism Paracoccus sediminicola strain SCSIO 76264

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAF18_RS16000 Protein ID WP_090525191.1
Coordinates 73333..73740 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAF18_RS15995 Protein ID WP_090525193.1
Coordinates 73113..73343 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAF18_RS15975 (PAF18_15975) 68553..69227 - 675 WP_271118238.1 hypothetical protein -
PAF18_RS15980 (PAF18_15980) 69227..69943 - 717 WP_271118239.1 AAA family ATPase -
PAF18_RS15985 (PAF18_15985) 70618..71163 + 546 WP_176805141.1 plasmid mobilization relaxosome protein MobC -
PAF18_RS15990 (PAF18_15990) 71160..73034 + 1875 WP_090525194.1 relaxase/mobilization nuclease domain-containing protein -
PAF18_RS15995 (PAF18_15995) 73113..73343 + 231 WP_090525193.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PAF18_RS16000 (PAF18_16000) 73333..73740 + 408 WP_090525191.1 PIN domain-containing protein Toxin
PAF18_RS16005 (PAF18_16005) 73967..74426 - 460 Protein_84 type I restriction endonuclease subunit R -
PAF18_RS16010 (PAF18_16010) 74562..74915 - 354 WP_176805139.1 PRC-barrel domain-containing protein -
PAF18_RS16015 (PAF18_16015) 75027..77486 - 2460 WP_090525189.1 DNA ligase D -
PAF18_RS16020 (PAF18_16020) 77487..78311 - 825 WP_271118175.1 Ku protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146119 146119
- flank IS/Tn - - 78594..79790 1196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)

Antitoxin

Antitoxin PemI-like

(2-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15069.29 Da        Isoelectric Point: 4.5642

>T267373 WP_090525191.1 NZ_CP115769:73333-73740 [Paracoccus sediminicola]
MPGRFFDTNILLYLLSDDRAKADIAEGLLRDGGTVSVQVLNEIANVTQRKFKMSWSQSDEFLLMIREFVTVEPLTYETHD
LGIALARKHTLSVYDAMIVAAGLLAGCDTVLSEDMQDGFRVADRITIRNPFAAQI

Download         Length: 408 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8795.09 Da        Isoelectric Point: 10.5712

>AT267373 WP_090525193.1 NZ_CP115769:73113-73343 [Paracoccus sediminicola]
MQIAKWGNSLAVRLPARMVQELGLKAGDEIEITATDAGHFQVRRRRDPEEILARLREFRGLMPKGYRFDRDEANAR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References