Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2833159..2834713 Replicon chromosome
Accession NZ_CP115768
Organism Paracoccus sediminicola strain SCSIO 76264

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PAF18_RS13900 Protein ID WP_271116292.1
Coordinates 2833412..2834713 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PAF18_RS13895 Protein ID WP_271116291.1
Coordinates 2833159..2833410 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAF18_RS13875 (PAF18_13875) 2828416..2829318 - 903 WP_271116287.1 lysylphosphatidylglycerol synthase transmembrane domain-containing protein -
PAF18_RS13880 (PAF18_13880) 2829315..2830913 - 1599 WP_271116288.1 sulfatase-like hydrolase/transferase -
PAF18_RS13885 (PAF18_13885) 2830913..2831656 - 744 WP_271116289.1 CDP-alcohol phosphatidyltransferase family protein -
PAF18_RS13890 (PAF18_13890) 2832155..2833018 + 864 WP_271116290.1 hypothetical protein -
PAF18_RS13895 (PAF18_13895) 2833159..2833410 + 252 WP_271116291.1 helix-turn-helix transcriptional regulator Antitoxin
PAF18_RS13900 (PAF18_13900) 2833412..2834713 + 1302 WP_271116292.1 type II toxin-antitoxin system HipA family toxin Toxin
PAF18_RS13905 (PAF18_13905) 2834757..2838203 - 3447 WP_271116293.1 YhaN family protein -
PAF18_RS13910 (PAF18_13910) 2838200..2839438 - 1239 WP_271116294.1 DNA repair exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47924.74 Da        Isoelectric Point: 6.0180

>T267372 WP_271116292.1 NZ_CP115768:2833412-2834713 [Paracoccus sediminicola]
MGRKRSYTPLNVFLNARLVGQLVRESSGGISFAYAREWLDWEHRMPVSLSLPLQENRTVGAPVMAVFDNLLPDSDLIRRR
VAERVGAEGVDAFSLLSQIGRDCIGALQFLPDGQSPQPMNELSGETVDDAQIEAILNDLDIAPLGIRRENDVRISVAGAQ
EKTALLRKDGQWIEPTGTTPTTHIIKPQIGRLPNGMDLSDSVENEFLCLKLMEAFGLRVAKAEMARFGEKKALVVERFDR
RWTSDGRLIRLPQEDCCQALSVVPTQKYQNEGGPRIADIMSLLLGSDDANTDRRDFFKANVLFWLLGATDGHGKNFSISL
LPGGRFRLTPLYDILTVQPTVDARQIERKQFRLAMSFGNSNHYKVADIVGRHLTETGVHSGLSRAAVQSLFDELQDTALE
RVDATLNRLPGDFPGALMSSIEAAVKARLCLLG

Download         Length: 1302 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9073.35 Da        Isoelectric Point: 6.4664

>AT267372 WP_271116291.1 NZ_CP115768:2833159-2833410 [Paracoccus sediminicola]
MKHLVRTPKNIGHAIREARKAKSLTQTDLAAMSGVWQETISKIENGSGGTKLETIFELLAALDLELTVTERSKGASDGFE
DIF

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References