Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2190843..2191357 Replicon chromosome
Accession NC_017351
Organism Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MS7_RS11280 Protein ID WP_000581792.1
Coordinates 2190843..2191052 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MS7_RS11285 Protein ID WP_000138932.1
Coordinates 2191064..2191357 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7_RS11260 2186351..2187709 - 1359 WP_000611480.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MS7_RS11265 2187724..2188794 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MS7_RS11270 2189112..2190314 + 1203 WP_001109939.1 rod shape-determining protein RodA -
MS7_RS11275 2190578..2190715 - 138 WP_000828354.1 hypothetical protein -
MS7_RS11280 2190843..2191052 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
MS7_RS11285 2191064..2191357 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MS7_RS11290 2191523..2193007 + 1485 WP_000571549.1 cardiolipin synthase -
MS7_RS11295 2193035..2193682 + 648 WP_001187630.1 HD domain-containing protein -
MS7_RS11300 2194148..2195020 - 873 WP_000725802.1 membrane protein insertase YidC -
MS7_RS11305 2195106..2195747 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T26736 WP_000581792.1 NC_017351:c2191052-2190843 [Staphylococcus aureus subsp. aureus 11819-97]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T26736 NC_017351:c2191052-2190843 [Staphylococcus aureus subsp. aureus 11819-97]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT26736 WP_000138932.1 NC_017351:c2191357-2191064 [Staphylococcus aureus subsp. aureus 11819-97]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26736 NC_017351:c2191357-2191064 [Staphylococcus aureus subsp. aureus 11819-97]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References