267358

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1359320..1360236 Replicon chromosome
Accession NZ_CP115738
Organism Bacillus subtilis strain W7

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag OSK17_RS07220 Protein ID WP_003244695.1
Coordinates 1359490..1360236 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag OSK17_RS07215 Protein ID WP_003232646.1
Coordinates 1359320..1359490 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSK17_RS07180 (1356183) 1356183..1356512 + 330 WP_041850928.1 XkdW family protein -
OSK17_RS07185 (1356509) 1356509..1356673 + 165 WP_041850927.1 XkdX family protein -
OSK17_RS07190 (1356717) 1356717..1357556 + 840 WP_041850926.1 phage-like element PBSX protein XepA -
OSK17_RS07195 (1357609) 1357609..1357878 + 270 WP_003232655.1 hemolysin XhlA family protein -
OSK17_RS07200 (1357891) 1357891..1358154 + 264 WP_003232653.1 phage holin -
OSK17_RS07205 (1358167) 1358167..1359060 + 894 WP_041850925.1 N-acetylmuramoyl-L-alanine amidase -
OSK17_RS07210 (1359097) 1359097..1359234 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
OSK17_RS07215 (1359320) 1359320..1359490 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
OSK17_RS07220 (1359490) 1359490..1360236 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
OSK17_RS07225 (1360346) 1360346..1361347 - 1002 WP_003232642.1 inorganic phosphate transporter -
OSK17_RS07230 (1361360) 1361360..1361977 - 618 WP_003218470.1 DUF47 domain-containing protein -
OSK17_RS07235 (1362253) 1362253..1363569 - 1317 WP_041850924.1 serine/threonine exchanger -
OSK17_RS07240 (1363957) 1363957..1364907 + 951 WP_041344800.1 ring-cleaving dioxygenase -
OSK17_RS07245 (1365008) 1365008..1365154 + 147 WP_120363335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T267358 WP_003244695.1 NZ_CP115738:c1360236-1359490 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT267358 WP_003232646.1 NZ_CP115738:c1359490-1359320 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References