Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 509883..510519 Replicon chromosome
Accession NZ_CP115738
Organism Bacillus subtilis strain W7

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag OSK17_RS02600 Protein ID WP_003156187.1
Coordinates 510169..510519 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag OSK17_RS02595 Protein ID WP_003225183.1
Coordinates 509883..510164 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSK17_RS02575 (506243) 506243..506842 - 600 WP_041850724.1 rhomboid family intramembrane serine protease -
OSK17_RS02580 (506937) 506937..507302 + 366 WP_015252768.1 holo-ACP synthase -
OSK17_RS02585 (507468) 507468..508484 + 1017 WP_072557167.1 outer membrane lipoprotein carrier protein LolA -
OSK17_RS02590 (508598) 508598..509767 + 1170 WP_015252766.1 alanine racemase -
OSK17_RS02595 (509883) 509883..510164 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
OSK17_RS02600 (510169) 510169..510519 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OSK17_RS02605 (510634) 510634..511458 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
OSK17_RS02610 (511463) 511463..511828 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
OSK17_RS02615 (511832) 511832..512233 + 402 WP_003246640.1 serine/threonine-protein kinase RsbT -
OSK17_RS02620 (512245) 512245..513252 + 1008 WP_003234295.1 phosphoserine phosphatase RsbU -
OSK17_RS02625 (513314) 513314..513643 + 330 WP_003234298.1 anti-sigma factor antagonist RsbV -
OSK17_RS02630 (513640) 513640..514122 + 483 WP_003234299.1 anti-sigma B factor RsbW -
OSK17_RS02635 (514088) 514088..514876 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
OSK17_RS02640 (514876) 514876..515475 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T267357 WP_003156187.1 NZ_CP115738:510169-510519 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT267357 WP_003225183.1 NZ_CP115738:509883-510164 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References