Detailed information of TA system TA267353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4852308..4853989
• Replicon: chromosome
• Accession: NZ_CP115714
• Organism: Klebsiella pneumoniae strain KPN0421

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: PF051_RS23760
• Protein ID: WP_004146663.1
• Coordinates: 4852308..4853225 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: PF051_RS23765
• Protein ID: WP_004177809.1
• Coordinates: 4853231..4853989 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PF051_RS23740 (4847614)	4847614..4849134	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
PF051_RS23745 (4849131)	4849131..4850129	+	999	WP_002885172.1	ribose ABC transporter permease	-
PF051_RS23750 (4850160)	4850160..4851101	+	942	WP_071081464.1	ABC transporter substrate-binding protein	-
PF051_RS23755 (4851176)	4851176..4852183	+	1008	WP_009484222.1	carbohydrate kinase family protein	-
PF051_RS23760 (4852308)	4852308..4853225	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PF051_RS23765 (4853231)	4853231..4853989	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
PF051_RS23770 (4854075)	4854075..4854803	-	729	WP_002885152.1	response regulator transcription factor	-
PF051_RS23775 (4855076)	4855076..4857223	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
PF051_RS23780 (4857453)	4857453..4858139	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T267353 WP_004146663.1 NZ_CP115714:c4853225-4852308 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT267353 WP_004177809.1 NZ_CP115714:c4853989-4853231 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05