Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4691822..4692338 Replicon chromosome
Accession NZ_CP115714
Organism Klebsiella pneumoniae strain KPN0421

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag PF051_RS22960 Protein ID WP_002886902.1
Coordinates 4691822..4692106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PF051_RS22965 Protein ID WP_002886901.1
Coordinates 4692096..4692338 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF051_RS22935 (4687238) 4687238..4687501 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
PF051_RS22940 (4687631) 4687631..4687804 + 174 WP_032408826.1 hypothetical protein -
PF051_RS22945 (4687807) 4687807..4688550 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PF051_RS22950 (4688907) 4688907..4691045 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PF051_RS22955 (4691354) 4691354..4691818 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PF051_RS22960 (4691822) 4691822..4692106 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF051_RS22965 (4692096) 4692096..4692338 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PF051_RS22970 (4692416) 4692416..4694326 - 1911 WP_009486549.1 PRD domain-containing protein -
PF051_RS22975 (4694349) 4694349..4695503 - 1155 WP_009309312.1 lactonase family protein -
PF051_RS22980 (4695570) 4695570..4696310 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T267352 WP_002886902.1 NZ_CP115714:c4692106-4691822 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT267352 WP_002886901.1 NZ_CP115714:c4692338-4692096 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References