Detailed information of TA system TA026735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2171086..2171615
• Replicon: chromosome
• Accession: NC_017351
• Organism: Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MS7_RS11190
• Protein ID: WP_000621175.1
• Coordinates: 2171086..2171448 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MS7_RS11195
• Protein ID: WP_000948331.1
• Coordinates: 2171445..2171615 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7_RS11165	2168064..2168834	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
MS7_RS11170	2168809..2169288	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
MS7_RS11175	2169290..2169616	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MS7_RS11180	2169735..2170736	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MS7_RS11190	2171086..2171448	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MS7_RS11195	2171445..2171615	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MS7_RS11200	2171700..2172848	-	1149	WP_001281154.1	alanine racemase	-
MS7_RS11205	2172914..2173273	-	360	WP_000581197.1	holo-ACP synthase	-
MS7_RS11210	2173277..2173768	-	492	WP_001205912.1	PH domain-containing protein	-
MS7_RS11215	2173755..2175338	-	1584	WP_001294621.1	PH domain-containing protein	-
MS7_RS11220	2175331..2175810	-	480	WP_001287079.1	hypothetical protein	-
MS7_RS11225	2176019..2176579	-	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26735 WP_000621175.1 NC_017351:c2171448-2171086 [Staphylococcus aureus subsp. aureus 11819-97]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26735 NC_017351:c2171448-2171086 [Staphylococcus aureus subsp. aureus 11819-97]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26735 WP_000948331.1 NC_017351:c2171615-2171445 [Staphylococcus aureus subsp. aureus 11819-97]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26735 NC_017351:c2171615-2171445 [Staphylococcus aureus subsp. aureus 11819-97]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGTTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1