Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2593121..2594709 Replicon chromosome
Accession NZ_CP115714
Organism Klebsiella pneumoniae strain KPN0421

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag PF051_RS12810 Protein ID WP_002904792.1
Coordinates 2593121..2594443 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PF051_RS12815 Protein ID WP_002904790.1
Coordinates 2594443..2594709 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF051_RS12795 (2588121) 2588121..2590622 + 2502 WP_064150654.1 fimbria/pilus outer membrane usher protein -
PF051_RS12800 (2590610) 2590610..2591614 + 1005 WP_009308876.1 fimbrial protein -
PF051_RS12805 (2591812) 2591812..2593104 + 1293 WP_032423495.1 glycoside hydrolase family 10 protein -
PF051_RS12810 (2593121) 2593121..2594443 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
PF051_RS12815 (2594443) 2594443..2594709 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PF051_RS12820 (2595096) 2595096..2595422 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PF051_RS12825 (2595419) 2595419..2595919 - 501 WP_032446037.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PF051_RS12830 (2595897) 2595897..2597276 - 1380 WP_071081018.1 nucleobase:cation symporter-2 family protein -
PF051_RS12835 (2597622) 2597622..2598776 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PF051_RS12840 (2598757) 2598757..2599680 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T267349 WP_002904792.1 NZ_CP115714:c2594443-2593121 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT267349 WP_002904790.1 NZ_CP115714:c2594709-2594443 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References