Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3755985..3756601 Replicon chromosome
Accession NZ_CP115712
Organism Kosakonia pseudosacchari strain RX.G5M8

Toxin (Protein)


Gene name Hha Uniprot ID A0A1G4ZCB1
Locus tag PF050_RS18015 Protein ID WP_017459990.1
Coordinates 3756383..3756601 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1G4ZCB5
Locus tag PF050_RS18010 Protein ID WP_017459991.1
Coordinates 3755985..3756359 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF050_RS18000 (PF050_18000) 3751092..3752285 + 1194 WP_086871137.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PF050_RS18005 (PF050_18005) 3752308..3755457 + 3150 WP_086871135.1 multidrug efflux RND transporter permease subunit AcrB -
PF050_RS18010 (PF050_18010) 3755985..3756359 + 375 WP_017459991.1 Hha toxicity modulator TomB Antitoxin
PF050_RS18015 (PF050_18015) 3756383..3756601 + 219 WP_017459990.1 HHA domain-containing protein Toxin
PF050_RS18020 (PF050_18020) 3756678..3757244 + 567 WP_271064349.1 maltose O-acetyltransferase -
PF050_RS18025 (PF050_18025) 3757346..3757825 + 480 WP_086871131.1 YlaC family protein -
PF050_RS18030 (PF050_18030) 3757791..3759239 - 1449 WP_271064350.1 PLP-dependent aminotransferase family protein -
PF050_RS18035 (PF050_18035) 3759339..3760040 + 702 WP_271064351.1 GNAT family protein -
PF050_RS18040 (PF050_18040) 3760037..3760177 - 141 WP_025263710.1 type B 50S ribosomal protein L36 -
PF050_RS18045 (PF050_18045) 3760181..3760441 - 261 WP_271064352.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8651.08 Da        Isoelectric Point: 7.9893

>T267332 WP_017459990.1 NZ_CP115712:3756383-3756601 [Kosakonia pseudosacchari]
MSEKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14550.41 Da        Isoelectric Point: 5.8346

>AT267332 WP_017459991.1 NZ_CP115712:3755985-3756359 [Kosakonia pseudosacchari]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIELIDEYL
DDTFMLFSSYGINTHDLQKWRKTGNKLFRSFVNVSKANPVSHSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4ZCB1

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4ZCB5

References