Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 75863..76509 Replicon chromosome
Accession NZ_CP115712
Organism Kosakonia pseudosacchari strain RX.G5M8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PF050_RS00385 Protein ID WP_086872353.1
Coordinates 76105..76509 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PF050_RS00380 Protein ID WP_176519654.1
Coordinates 75863..76105 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF050_RS00355 (PF050_00355) 71628..72023 - 396 WP_086872338.1 cupin domain-containing protein -
PF050_RS00360 (PF050_00360) 72246..73409 - 1164 WP_271064795.1 multidrug effflux MFS transporter -
PF050_RS00365 (PF050_00365) 73520..74122 - 603 WP_271064796.1 helix-turn-helix domain-containing protein -
PF050_RS00370 (PF050_00370) 74168..74860 + 693 WP_271064797.1 B3/4 domain-containing protein -
PF050_RS00375 (PF050_00375) 74871..75752 + 882 WP_271064798.1 dihydrodipicolinate synthase family protein -
PF050_RS00380 (PF050_00380) 75863..76105 + 243 WP_176519654.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PF050_RS00385 (PF050_00385) 76105..76509 + 405 WP_086872353.1 tRNA(fMet)-specific endonuclease VapC Toxin
PF050_RS00390 (PF050_00390) 76506..77576 - 1071 WP_271064799.1 AbrB family transcriptional regulator -
PF050_RS00395 (PF050_00395) 78442..79116 + 675 WP_271064800.1 LuxR C-terminal-related transcriptional regulator -
PF050_RS00400 (PF050_00400) 79231..80334 + 1104 WP_271064801.1 alkene reductase -
PF050_RS00405 (PF050_00405) 80383..80664 - 282 WP_065369673.1 hypothetical protein -
PF050_RS00410 (PF050_00410) 80904..81212 - 309 WP_020455769.1 SymE family type I addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-58)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14795.18 Da        Isoelectric Point: 8.5190

>T267320 WP_086872353.1 NZ_CP115712:76105-76509 [Kosakonia pseudosacchari]
MLKFMLDTNICIFTIKNKPEIVRQAFNQHSGQMCISSVTLMELIYGAEKSAIPEKNLRVVEGFTARLEVLPYGVDAAVHT
GQLRAELARAGTPVGPYDAMIGAHARSLGLVLVSNNTREFARIPGLRLQDWTSH

Download         Length: 405 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9061.09 Da        Isoelectric Point: 4.5098

>AT267320 WP_176519654.1 NZ_CP115712:75863-76105 [Kosakonia pseudosacchari]
MEARVEKTTLFKSNRSQAVRLPKAVALPEDVKHVDIIAVGRTRIITPSGEAWDSWFDGESASPDFMAAREQPEEQDREDF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References