Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 34623..35266 | Replicon | plasmid pCPE16_3 |
Accession | NZ_CP115709 | ||
Organism | Klebsiella pneumoniae strain CPE16 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | D8L2J9 |
Locus tag | PGD48_RS27205 | Protein ID | WP_001044770.1 |
Coordinates | 34623..35039 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | D5KTK7 |
Locus tag | PGD48_RS27210 | Protein ID | WP_001261282.1 |
Coordinates | 35036..35266 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PGD48_RS27170 (PGD48_27165) | 30165..30401 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
PGD48_RS27175 (PGD48_27170) | 30398..30760 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
PGD48_RS27180 (PGD48_27175) | 30778..32472 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
PGD48_RS27185 (PGD48_27180) | 32524..32946 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
PGD48_RS27190 (PGD48_27185) | 32982..33092 | - | 111 | Protein_40 | mercuric transport protein periplasmic component | - |
PGD48_RS27200 (PGD48_27195) | 33860..34549 | - | 690 | Protein_42 | AAA family ATPase | - |
PGD48_RS27205 (PGD48_27200) | 34623..35039 | - | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
PGD48_RS27210 (PGD48_27205) | 35036..35266 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
PGD48_RS27215 (PGD48_27210) | 35223..35682 | + | 460 | Protein_45 | hypothetical protein | - |
PGD48_RS27220 (PGD48_27215) | 36169..36477 | + | 309 | WP_004152336.1 | hypothetical protein | - |
PGD48_RS27225 (PGD48_27220) | 36505..36834 | + | 330 | WP_004152337.1 | hypothetical protein | - |
PGD48_RS27230 (PGD48_27225) | 36860..37258 | + | 399 | WP_004171440.1 | hypothetical protein | - |
PGD48_RS27235 (PGD48_27230) | 37265..37597 | + | 333 | WP_004152339.1 | hypothetical protein | - |
PGD48_RS27240 (PGD48_27235) | 37597..38379 | + | 783 | WP_004152340.1 | site-specific integrase | - |
PGD48_RS27245 (PGD48_27240) | 39271..39501 | - | 231 | WP_011977773.1 | hypothetical protein | - |
PGD48_RS27250 (PGD48_27245) | 39593..40066 | - | 474 | WP_004152341.1 | YkgJ family cysteine cluster protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaNDM-1 / aph(3')-VI / qnrS1 / blaCTX-M-15 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 / blaTEM-1B | - | 1..119165 | 119165 | |
- | flank | IS/Tn | - | - | 40186..41454 | 1268 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T267319 WP_001044770.1 NZ_CP115709:c35039-34623 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GYM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GZG3 |