267318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 168710..169232 Replicon plasmid pCPE16_2
Accession NZ_CP115708
Organism Klebsiella pneumoniae strain CPE16

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag PGD48_RS26600 Protein ID WP_038991638.1
Coordinates 168948..169232 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag PGD48_RS26595 Protein ID WP_004181777.1
Coordinates 168710..168958 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGD48_RS26575 (PGD48_26570) 163919..164740 - 822 WP_004181772.1 hypothetical protein -
PGD48_RS26580 (PGD48_26575) 164802..165155 - 354 WP_004181774.1 hypothetical protein -
PGD48_RS26585 (PGD48_26580) 165300..166286 - 987 WP_040120328.1 hypothetical protein -
PGD48_RS26590 (PGD48_26585) 166620..168419 - 1800 WP_043907032.1 ATP-dependent helicase -
PGD48_RS26595 (PGD48_26590) 168710..168958 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PGD48_RS26600 (PGD48_26595) 168948..169232 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGD48_RS26605 (PGD48_26600) 169249..169350 - 102 Protein_183 IS200/IS605 family transposase -
PGD48_RS26610 (PGD48_26605) 169386..170612 + 1227 WP_040120327.1 RNA-guided endonuclease TnpB family protein -
PGD48_RS26615 (PGD48_26610) 170884..171108 - 225 Protein_185 transposase -
PGD48_RS26620 (PGD48_26615) 171187..171615 - 429 WP_077256229.1 IS200/IS605 family transposase -
PGD48_RS26625 (PGD48_26620) 171651..172838 + 1188 WP_043907031.1 RNA-guided endonuclease TnpB family protein -
PGD48_RS26630 (PGD48_26625) 172883..173254 - 372 WP_044816264.1 hypothetical protein -
PGD48_RS26635 (PGD48_26630) 173251..173595 - 345 WP_014386518.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..248840 248840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T267318 WP_038991638.1 NZ_CP115708:168948-169232 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT267318 WP_004181777.1 NZ_CP115708:168710-168958 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References