267317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 109780..110531 Replicon plasmid pCPE16_2
Accession NZ_CP115708
Organism Klebsiella pneumoniae strain CPE16

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag PGD48_RS26275 Protein ID WP_014386536.1
Coordinates 109780..110262 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag PGD48_RS26280 Protein ID WP_004902250.1
Coordinates 110253..110531 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGD48_RS26255 (PGD48_26250) 106179..106826 - 648 WP_014386537.1 EcsC family protein -
PGD48_RS26260 (PGD48_26255) 106853..107608 - 756 WP_004902235.1 DUF2971 domain-containing protein -
PGD48_RS26265 (PGD48_26260) 107709..108101 - 393 WP_032442757.1 hypothetical protein -
PGD48_RS26270 (PGD48_26265) 108206..108745 - 540 WP_004902239.1 hypothetical protein -
PGD48_RS26275 (PGD48_26270) 109780..110262 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
PGD48_RS26280 (PGD48_26275) 110253..110531 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
PGD48_RS26285 (PGD48_26280) 110650..110862 - 213 WP_004902255.1 hypothetical protein -
PGD48_RS26290 (PGD48_26285) 110970..111311 - 342 WP_004902257.1 hypothetical protein -
PGD48_RS26295 (PGD48_26290) 112141..112599 - 459 WP_014386535.1 hypothetical protein -
PGD48_RS26300 (PGD48_26295) 113252..113707 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
PGD48_RS26305 (PGD48_26300) 113779..114144 + 366 WP_004200999.1 mercuric ion transporter MerT -
PGD48_RS26310 (PGD48_26305) 114160..114435 + 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
PGD48_RS26315 (PGD48_26310) 114463..114888 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..248840 248840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T267317 WP_014386536.1 NZ_CP115708:c110262-109780 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT267317 WP_004902250.1 NZ_CP115708:c110531-110253 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References