Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 34921..35831 | Replicon | plasmid pCPE16_2 |
| Accession | NZ_CP115708 | ||
| Organism | Klebsiella pneumoniae strain CPE16 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | PGD48_RS25905 | Protein ID | WP_004181896.1 |
| Coordinates | 35361..35831 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | PGD48_RS25900 | Protein ID | WP_004181895.1 |
| Coordinates | 34921..35364 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PGD48_RS25885 (PGD48_25880) | 31554..33041 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| PGD48_RS25890 (PGD48_25885) | 33127..33549 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| PGD48_RS25895 (PGD48_25890) | 33549..34820 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PGD48_RS25900 (PGD48_25895) | 34921..35364 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| PGD48_RS25905 (PGD48_25900) | 35361..35831 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| PGD48_RS25910 (PGD48_25905) | 35941..36201 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| PGD48_RS25915 (PGD48_25910) | 36772..37953 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
| PGD48_RS25920 (PGD48_25915) | 38025..38183 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| PGD48_RS25925 (PGD48_25920) | 38786..39760 | + | 975 | WP_043907013.1 | hypothetical protein | - |
| PGD48_RS25930 (PGD48_25925) | 39958..40335 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | - | 1..248840 | 248840 | |
| - | flank | IS/Tn | - | - | 36772..37953 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T267316 WP_004181896.1 NZ_CP115708:35361-35831 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT267316 WP_004181895.1 NZ_CP115708:34921-35364 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |