Detailed information of TA system TA267314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4888411..4890092
• Replicon: chromosome
• Accession: NZ_CP115707
• Organism: Klebsiella pneumoniae strain CPE16

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: PGD48_RS23815
• Protein ID: WP_004178299.1
• Coordinates: 4888411..4889328 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: PGD48_RS23820
• Protein ID: WP_004177809.1
• Coordinates: 4889334..4890092 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PGD48_RS23795 (4883717)	4883717..4885237	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
PGD48_RS23800 (4885234)	4885234..4886232	+	999	WP_002885172.1	ribose ABC transporter permease	-
PGD48_RS23805 (4886263)	4886263..4887204	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
PGD48_RS23810 (4887279)	4887279..4888286	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
PGD48_RS23815 (4888411)	4888411..4889328	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PGD48_RS23820 (4889334)	4889334..4890092	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
PGD48_RS23825 (4890178)	4890178..4890906	-	729	WP_004178298.1	response regulator transcription factor	-
PGD48_RS23830 (4891179)	4891179..4893326	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
PGD48_RS23835 (4893556)	4893556..4894242	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T267314 WP_004178299.1 NZ_CP115707:c4889328-4888411 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT267314 WP_004177809.1 NZ_CP115707:c4890092-4889334 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05