Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4888411..4890092 | Replicon | chromosome |
| Accession | NZ_CP115707 | ||
| Organism | Klebsiella pneumoniae strain CPE16 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | PGD48_RS23815 | Protein ID | WP_004178299.1 |
| Coordinates | 4888411..4889328 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | PGD48_RS23820 | Protein ID | WP_004177809.1 |
| Coordinates | 4889334..4890092 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PGD48_RS23795 (4883717) | 4883717..4885237 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| PGD48_RS23800 (4885234) | 4885234..4886232 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| PGD48_RS23805 (4886263) | 4886263..4887204 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| PGD48_RS23810 (4887279) | 4887279..4888286 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| PGD48_RS23815 (4888411) | 4888411..4889328 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PGD48_RS23820 (4889334) | 4889334..4890092 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| PGD48_RS23825 (4890178) | 4890178..4890906 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
| PGD48_RS23830 (4891179) | 4891179..4893326 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| PGD48_RS23835 (4893556) | 4893556..4894242 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T267314 WP_004178299.1 NZ_CP115707:c4889328-4888411 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT267314 WP_004177809.1 NZ_CP115707:c4890092-4889334 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|