Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4732716..4733232 Replicon chromosome
Accession NZ_CP115707
Organism Klebsiella pneumoniae strain CPE16

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag PGD48_RS23020 Protein ID WP_004178374.1
Coordinates 4732716..4733000 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PGD48_RS23025 Protein ID WP_002886901.1
Coordinates 4732990..4733232 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGD48_RS22995 (4728200) 4728200..4728463 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
PGD48_RS23000 (4728593) 4728593..4728766 + 174 WP_032408826.1 hypothetical protein -
PGD48_RS23005 (4728769) 4728769..4729512 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PGD48_RS23010 (4729869) 4729869..4732007 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PGD48_RS23015 (4732248) 4732248..4732712 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PGD48_RS23020 (4732716) 4732716..4733000 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGD48_RS23025 (4732990) 4732990..4733232 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PGD48_RS23030 (4733310) 4733310..4735220 - 1911 WP_004178373.1 PRD domain-containing protein -
PGD48_RS23035 (4735243) 4735243..4736397 - 1155 WP_004178372.1 lactonase family protein -
PGD48_RS23040 (4736464) 4736464..4737204 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T267313 WP_004178374.1 NZ_CP115707:c4733000-4732716 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT267313 WP_002886901.1 NZ_CP115707:c4733232-4732990 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References