Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2714537..2716125 Replicon chromosome
Accession NZ_CP115707
Organism Klebsiella pneumoniae strain CPE16

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PGD48_RS13495 Protein ID WP_004179815.1
Coordinates 2714537..2715859 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PGD48_RS13500 Protein ID WP_004176198.1
Coordinates 2715859..2716125 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGD48_RS13480 (2709593) 2709593..2712094 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
PGD48_RS13485 (2712082) 2712082..2713086 + 1005 WP_004179822.1 fimbrial protein -
PGD48_RS13490 (2713228) 2713228..2714520 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PGD48_RS13495 (2714537) 2714537..2715859 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
PGD48_RS13500 (2715859) 2715859..2716125 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PGD48_RS13505 (2716391) 2716391..2716717 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PGD48_RS13510 (2716714) 2716714..2717214 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PGD48_RS13515 (2717192) 2717192..2718571 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
PGD48_RS13520 (2718917) 2718917..2720071 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PGD48_RS13525 (2720052) 2720052..2720975 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T267309 WP_004179815.1 NZ_CP115707:c2715859-2714537 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT267309 WP_004176198.1 NZ_CP115707:c2716125-2715859 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References