Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 813802..814459 Replicon chromosome
Accession NZ_CP115707
Organism Klebsiella pneumoniae strain CPE16

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PGD48_RS03995 Protein ID WP_004181233.1
Coordinates 814049..814459 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PGD48_RS03990 Protein ID WP_002916312.1
Coordinates 813802..814068 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGD48_RS03965 (808958) 808958..810391 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
PGD48_RS03970 (810510) 810510..811238 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PGD48_RS03975 (811288) 811288..811599 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PGD48_RS03980 (811763) 811763..812422 + 660 WP_002916317.1 hemolysin III family protein -
PGD48_RS03985 (812573) 812573..813556 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
PGD48_RS03990 (813802) 813802..814068 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PGD48_RS03995 (814049) 814049..814459 + 411 WP_004181233.1 protein YgfX Toxin
PGD48_RS04000 (814466) 814466..814987 - 522 WP_004144730.1 flavodoxin FldB -
PGD48_RS04005 (815088) 815088..815984 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PGD48_RS04010 (816007) 816007..816720 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PGD48_RS04015 (816726) 816726..818459 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T267304 WP_004181233.1 NZ_CP115707:814049-814459 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT267304 WP_002916312.1 NZ_CP115707:813802-814068 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References