Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4923342..4925023 Replicon chromosome
Accession NZ_CP115701
Organism Klebsiella pneumoniae strain 2020CK-00201

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag PF326_RS24565 Protein ID WP_002885155.1
Coordinates 4923342..4924259 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag PF326_RS24570 Protein ID WP_004151732.1
Coordinates 4924265..4925023 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF326_RS24545 (PF326_24545) 4918648..4920168 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PF326_RS24550 (PF326_24550) 4920165..4921163 + 999 WP_002885172.1 ribose ABC transporter permease -
PF326_RS24555 (PF326_24555) 4921194..4922135 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PF326_RS24560 (PF326_24560) 4922210..4923217 + 1008 WP_004151731.1 carbohydrate kinase family protein -
PF326_RS24565 (PF326_24565) 4923342..4924259 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PF326_RS24570 (PF326_24570) 4924265..4925023 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PF326_RS24575 (PF326_24575) 4925109..4925837 - 729 WP_002885152.1 response regulator transcription factor -
PF326_RS24580 (PF326_24580) 4926110..4928257 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
PF326_RS24585 (PF326_24585) 4928487..4929173 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T267301 WP_002885155.1 NZ_CP115701:c4924259-4923342 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT267301 WP_004151732.1 NZ_CP115701:c4925023-4924265 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References