Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4763310..4763826 Replicon chromosome
Accession NZ_CP115701
Organism Klebsiella pneumoniae strain 2020CK-00201

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag PF326_RS23740 Protein ID WP_002886902.1
Coordinates 4763310..4763594 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PF326_RS23745 Protein ID WP_002886901.1
Coordinates 4763584..4763826 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF326_RS23715 (PF326_23715) 4758794..4759057 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
PF326_RS23720 (PF326_23720) 4759187..4759360 + 174 WP_002886906.1 hypothetical protein -
PF326_RS23725 (PF326_23725) 4759363..4760106 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PF326_RS23730 (PF326_23730) 4760463..4762601 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
PF326_RS23735 (PF326_23735) 4762842..4763306 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PF326_RS23740 (PF326_23740) 4763310..4763594 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF326_RS23745 (PF326_23745) 4763584..4763826 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PF326_RS23750 (PF326_23750) 4763904..4765814 - 1911 WP_004152270.1 PRD domain-containing protein -
PF326_RS23755 (PF326_23755) 4765837..4766991 - 1155 WP_002886900.1 lactonase family protein -
PF326_RS23760 (PF326_23760) 4767057..4767797 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T267300 WP_002886902.1 NZ_CP115701:c4763594-4763310 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT267300 WP_002886901.1 NZ_CP115701:c4763826-4763584 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References