Detailed information of TA system TA026730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1975436..1976212
• Replicon: chromosome
• Accession: NC_017351
• Organism: Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MS7_RS09945
• Protein ID: WP_000031108.1
• Coordinates: 1975436..1975588 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MS7_RS09950
• Protein ID: WP_001251231.1
• Coordinates: 1975613..1976212 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7_RS09930	1971162..1971983	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
MS7_RS09935	1972446..1973831	-	1386	WP_000116231.1	class II fumarate hydratase	-
MS7_RS09940	1974027..1974422	-	396	WP_000901023.1	hypothetical protein	-
MS7_RS09945	1975436..1975588	-	153	WP_000031108.1	hypothetical protein	Toxin
MS7_RS09950	1975613..1976212	-	600	WP_001251231.1	glucosamine-6-phosphate isomerase	Antitoxin
MS7_RS09955	1976372..1976842	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MS7_RS09960	1976847..1977974	-	1128	WP_000379986.1	tRNA epoxyqueuosine(34) reductase QueG	-
MS7_RS09965	1978125..1978847	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MS7_RS09970	1978840..1980297	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T26730 WP_000031108.1 NC_017351:c1975588-1975436 [Staphylococcus aureus subsp. aureus 11819-97]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T26730 NC_017351:c1975588-1975436 [Staphylococcus aureus subsp. aureus 11819-97]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22342.49 Da
• Isoelectric Point: 5.3880

>AT26730 WP_001251231.1 NC_017351:c1976212-1975613 [Staphylococcus aureus subsp. aureus 11819-97]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLNELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT26730 NC_017351:c1976212-1975613 [Staphylococcus aureus subsp. aureus 11819-97]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAAATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: X5E2E6