Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2743402..2744990 Replicon chromosome
Accession NZ_CP115701
Organism Klebsiella pneumoniae strain 2020CK-00201

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag PF326_RS13720 Protein ID WP_002904792.1
Coordinates 2743402..2744724 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PF326_RS13725 Protein ID WP_002904790.1
Coordinates 2744724..2744990 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF326_RS13705 (PF326_13705) 2738458..2740959 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
PF326_RS13710 (PF326_13710) 2740947..2741951 + 1005 WP_002904798.1 fimbrial protein -
PF326_RS13715 (PF326_13715) 2742093..2743385 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PF326_RS13720 (PF326_13720) 2743402..2744724 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
PF326_RS13725 (PF326_13725) 2744724..2744990 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PF326_RS13730 (PF326_13730) 2745256..2745582 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PF326_RS13735 (PF326_13735) 2745579..2746079 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PF326_RS13740 (PF326_13740) 2746057..2747436 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
PF326_RS13745 (PF326_13745) 2747782..2748936 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PF326_RS13750 (PF326_13750) 2748917..2749840 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T267297 WP_002904792.1 NZ_CP115701:c2744724-2743402 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT267297 WP_002904790.1 NZ_CP115701:c2744990-2744724 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References