Detailed information of TA system TA026729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1600535..1601332
• Replicon: chromosome
• Accession: NC_017351
• Organism: Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A641AAS6
• Locus tag: MS7_RS08025
• Protein ID: WP_000525006.1
• Coordinates: 1600871..1601332 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MS7_RS08020
• Protein ID: WP_001260486.1
• Coordinates: 1600535..1600858 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS7_RS07970	1596270..1596827	-	558	WP_000645042.1	DUF2815 family protein	-
MS7_RS07975	1596853..1598019	-	1167	WP_000762551.1	DUF2800 domain-containing protein	-
MS7_RS07980	1598016..1598378	-	363	WP_000279446.1	hypothetical protein	-
MS7_RS07985	1598393..1598716	-	324	WP_000175000.1	hypothetical protein	-
MS7_RS07990	1598796..1598957	-	162	WP_001285955.1	DUF1270 family protein	-
MS7_RS07995	1598970..1599233	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MS7_RS08000	1599258..1599473	-	216	WP_001036301.1	hypothetical protein	-
MS7_RS08005	1599528..1599893	+	366	WP_001128433.1	hypothetical protein	-
MS7_RS08010	1599862..1600107	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
MS7_RS08015	1600123..1600371	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MS7_RS08020	1600535..1600858	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	Antitoxin
MS7_RS08025	1600871..1601332	+	462	WP_000525006.1	hypothetical protein	Toxin
MS7_RS08030	1601349..1601783	+	435	WP_001226136.1	hypothetical protein	-
MS7_RS08035	1601812..1602207	+	396	WP_000449655.1	hypothetical protein	-
MS7_RS08040	1602297..1602443	+	147	WP_001013104.1	hypothetical protein	-
MS7_RS08045	1602440..1603054	-	615	WP_000191459.1	hypothetical protein	-
MS7_RS15035	1603180..1604386	+	1207	Protein_1529	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1555838..1622028	66190

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18118.47 Da
• Isoelectric Point: 4.6915

>T26729 WP_000525006.1 NC_017351:1600871-1601332 [Staphylococcus aureus subsp. aureus 11819-97]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T26729 NC_017351:1600871-1601332 [Staphylococcus aureus subsp. aureus 11819-97]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12427.10 Da
• Isoelectric Point: 9.3811

>AT26729 WP_001260486.1 NC_017351:1600535-1600858 [Staphylococcus aureus subsp. aureus 11819-97]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT26729 NC_017351:1600535-1600858 [Staphylococcus aureus subsp. aureus 11819-97]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Toxin

• AlphaFold DB: A0A641AAS6