Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4658223..4658839 Replicon chromosome
Accession NZ_CP115696
Organism Enterobacter hormaechei strain 2020CK-00202

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PF328_RS22205 Protein ID WP_015569913.1
Coordinates 4658223..4658594 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag PF328_RS22210 Protein ID WP_015569912.1
Coordinates 4658597..4658839 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF328_RS22190 (PF328_22190) 4655723..4656625 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
PF328_RS22195 (PF328_22195) 4656622..4657257 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
PF328_RS22200 (PF328_22200) 4657254..4658183 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PF328_RS22205 (PF328_22205) 4658223..4658594 - 372 WP_015569913.1 PIN domain-containing protein Toxin
PF328_RS22210 (PF328_22210) 4658597..4658839 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
PF328_RS22215 (PF328_22215) 4659038..4659958 + 921 WP_015569911.1 alpha/beta hydrolase -
PF328_RS22220 (PF328_22220) 4659967..4660908 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PF328_RS22225 (PF328_22225) 4660953..4661390 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PF328_RS22230 (PF328_22230) 4661387..4662268 - 882 WP_003861949.1 virulence factor BrkB family protein -
PF328_RS22235 (PF328_22235) 4662262..4662861 - 600 WP_017694048.1 glucose-1-phosphatase -
PF328_RS22240 (PF328_22240) 4662980..4663780 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T267287 WP_015569913.1 NZ_CP115696:c4658594-4658223 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT267287 WP_015569912.1 NZ_CP115696:c4658839-4658597 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References