Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3795011..3795668 Replicon chromosome
Accession NZ_CP115696
Organism Enterobacter hormaechei strain 2020CK-00202

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag PF328_RS18005 Protein ID WP_023295382.1
Coordinates 3795011..3795421 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PF328_RS18010 Protein ID WP_003863437.1
Coordinates 3795402..3795668 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF328_RS17985 (PF328_17985) 3791009..3792742 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
PF328_RS17990 (PF328_17990) 3792748..3793461 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PF328_RS17995 (PF328_17995) 3793490..3794386 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PF328_RS18000 (PF328_18000) 3794488..3795009 + 522 WP_015571793.1 flavodoxin FldB -
PF328_RS18005 (PF328_18005) 3795011..3795421 - 411 WP_023295382.1 protein YgfX Toxin
PF328_RS18010 (PF328_18010) 3795402..3795668 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PF328_RS18015 (PF328_18015) 3795963..3796943 + 981 WP_039269839.1 tRNA-modifying protein YgfZ -
PF328_RS18020 (PF328_18020) 3797055..3797714 - 660 WP_003863433.1 hemolysin III family protein -
PF328_RS18025 (PF328_18025) 3797981..3798709 + 729 WP_039269836.1 MurR/RpiR family transcriptional regulator -
PF328_RS18030 (PF328_18030) 3798829..3800262 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T267286 WP_023295382.1 NZ_CP115696:c3795421-3795011 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT267286 WP_003863437.1 NZ_CP115696:c3795668-3795402 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References