Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2307837..2308576 Replicon chromosome
Accession NZ_CP115696
Organism Enterobacter hormaechei strain 2020CK-00202

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag PF328_RS11030 Protein ID WP_003857133.1
Coordinates 2307837..2308322 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PF328_RS11035 Protein ID WP_003857131.1
Coordinates 2308310..2308576 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF328_RS11005 (PF328_11005) 2303381..2304139 - 759 WP_017693420.1 trans-aconitate 2-methyltransferase -
PF328_RS11010 (PF328_11010) 2304224..2304808 - 585 WP_039270753.1 NUDIX domain-containing protein -
PF328_RS11015 (PF328_11015) 2304895..2305653 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
PF328_RS11020 (PF328_11020) 2305758..2307050 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
PF328_RS11025 (PF328_11025) 2307050..2307664 + 615 WP_080338042.1 NUDIX hydrolase -
PF328_RS11030 (PF328_11030) 2307837..2308322 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
PF328_RS11035 (PF328_11035) 2308310..2308576 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PF328_RS11040 (PF328_11040) 2308640..2309569 - 930 WP_039270752.1 LysR family transcriptional regulator -
PF328_RS11045 (PF328_11045) 2309699..2311081 + 1383 WP_039270751.1 MFS transporter -
PF328_RS11050 (PF328_11050) 2311103..2312098 - 996 WP_271039689.1 DUF2891 domain-containing protein -
PF328_RS11055 (PF328_11055) 2312108..2313094 - 987 WP_023296632.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2294473..2308576 14103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T267280 WP_003857133.1 NZ_CP115696:c2308322-2307837 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T267280 NZ_CP115696:c2308322-2307837 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGGAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT267280 WP_003857131.1 NZ_CP115696:c2308576-2308310 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT267280 NZ_CP115696:c2308576-2308310 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References