Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1102665..1103285 Replicon chromosome
Accession NZ_CP115696
Organism Enterobacter hormaechei strain 2020CK-00202

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PF328_RS05175 Protein ID WP_015571250.1
Coordinates 1102665..1102883 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PF328_RS05180 Protein ID WP_006809850.1
Coordinates 1102911..1103285 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF328_RS05145 (PF328_05145) 1098677..1098937 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
PF328_RS05150 (PF328_05150) 1098940..1099080 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PF328_RS05155 (PF328_05155) 1099077..1099787 - 711 WP_032670463.1 GNAT family protein -
PF328_RS05160 (PF328_05160) 1099889..1101349 + 1461 WP_039271537.1 PLP-dependent aminotransferase family protein -
PF328_RS05165 (PF328_05165) 1101321..1101788 - 468 WP_023296041.1 YlaC family protein -
PF328_RS05170 (PF328_05170) 1101905..1102456 - 552 WP_015571251.1 maltose O-acetyltransferase -
PF328_RS05175 (PF328_05175) 1102665..1102883 - 219 WP_015571250.1 HHA domain-containing protein Toxin
PF328_RS05180 (PF328_05180) 1102911..1103285 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PF328_RS05185 (PF328_05185) 1103796..1106942 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
PF328_RS05190 (PF328_05190) 1106965..1108158 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T267279 WP_015571250.1 NZ_CP115696:c1102883-1102665 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT267279 WP_006809850.1 NZ_CP115696:c1103285-1102911 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References