267277

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 68428..68954 Replicon plasmid unnamed1
Accession NZ_CP115690
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PF325_RS24335 Protein ID WP_000323025.1
Coordinates 68428..68715 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PF325_RS24340 Protein ID WP_000534858.1
Coordinates 68715..68954 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS24295 (PF325_24295) 63549..64016 - 468 WP_127312814.1 hypothetical protein -
PF325_RS24300 (PF325_24300) 64009..64431 - 423 WP_045620781.1 MgtC/SapB family protein -
PF325_RS24305 (PF325_24305) 64428..64721 - 294 WP_047723347.1 hypothetical protein -
PF325_RS24310 (PF325_24310) 64735..66138 - 1404 WP_045620748.1 F-type conjugal transfer pilus assembly protein TraB -
PF325_RS24315 (PF325_24315) 66141..66800 - 660 WP_271040833.1 F-type conjugal transfer protein TraK -
PF325_RS24320 (PF325_24320) 66739..66897 - 159 WP_223861909.1 hypothetical protein -
PF325_RS24325 (PF325_24325) 67007..67321 - 315 WP_045620735.1 hypothetical protein -
PF325_RS24330 (PF325_24330) 68202..68375 - 174 WP_230676869.1 DUF5431 family protein -
PF325_RS24335 (PF325_24335) 68428..68715 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PF325_RS24340 (PF325_24340) 68715..68954 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PF325_RS24345 (PF325_24345) 68979..69083 + 105 Protein_69 protein YdfV -
PF325_RS24350 (PF325_24350) 69217..70140 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
PF325_RS24355 (PF325_24355) 70340..70543 - 204 Protein_71 cytochrome b/b6 domain-containing protein -
PF325_RS24360 (PF325_24360) 70612..71592 + 981 WP_057058223.1 IS5-like element IS5 family transposase -
PF325_RS24365 (PF325_24365) 71982..73016 + 1035 Protein_73 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..136056 136056


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T267277 WP_000323025.1 NZ_CP115690:c68715-68428 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT267277 WP_000534858.1 NZ_CP115690:c68954-68715 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References