267276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4851896..4852512 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PF325_RS23610 Protein ID WP_015569913.1
Coordinates 4851896..4852267 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag PF325_RS23615 Protein ID WP_015569912.1
Coordinates 4852270..4852512 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS23595 (PF325_23595) 4849396..4850298 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
PF325_RS23600 (PF325_23600) 4850295..4850930 + 636 WP_252051972.1 formate dehydrogenase cytochrome b556 subunit -
PF325_RS23605 (PF325_23605) 4850927..4851856 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PF325_RS23610 (PF325_23610) 4851896..4852267 - 372 WP_015569913.1 PIN domain-containing protein Toxin
PF325_RS23615 (PF325_23615) 4852270..4852512 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
PF325_RS23620 (PF325_23620) 4852711..4853631 + 921 WP_015569911.1 alpha/beta hydrolase -
PF325_RS23625 (PF325_23625) 4853640..4854581 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PF325_RS23630 (PF325_23630) 4854626..4855063 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PF325_RS23635 (PF325_23635) 4855060..4855941 - 882 WP_003861949.1 virulence factor BrkB family protein -
PF325_RS23640 (PF325_23640) 4855935..4856534 - 600 WP_017694048.1 glucose-1-phosphatase -
PF325_RS23645 (PF325_23645) 4856653..4857453 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T267276 WP_015569913.1 NZ_CP115689:c4852267-4851896 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT267276 WP_015569912.1 NZ_CP115689:c4852512-4852270 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References