267275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4723259..4723863 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag PF325_RS23040 Protein ID WP_071788668.1
Coordinates 4723678..4723863 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag PF325_RS23035 Protein ID WP_023295606.1
Coordinates 4723259..4723663 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS23020 (PF325_23020) 4718799..4719617 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
PF325_RS23025 (PF325_23025) 4719843..4721243 + 1401 WP_017693791.1 MFS transporter -
PF325_RS23030 (PF325_23030) 4721254..4723203 + 1950 WP_271040488.1 glycoside hydrolase family 127 protein -
PF325_RS23035 (PF325_23035) 4723259..4723663 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PF325_RS23040 (PF325_23040) 4723678..4723863 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
PF325_RS23045 (PF325_23045) 4724113..4725651 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
PF325_RS23050 (PF325_23050) 4725818..4726702 + 885 WP_015572761.1 ROK family protein -
PF325_RS23055 (PF325_23055) 4726706..4728544 - 1839 WP_023295607.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T267275 WP_071788668.1 NZ_CP115689:c4723863-4723678 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT267275 WP_023295606.1 NZ_CP115689:c4723663-4723259 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References