Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4042743..4043400 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag PF325_RS19740 Protein ID WP_017382887.1
Coordinates 4042743..4043153 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PF325_RS19745 Protein ID WP_003863437.1
Coordinates 4043134..4043400 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS19720 (PF325_19720) 4038741..4040474 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
PF325_RS19725 (PF325_19725) 4040480..4041193 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PF325_RS19730 (PF325_19730) 4041222..4042118 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PF325_RS19735 (PF325_19735) 4042220..4042741 + 522 WP_015571793.1 flavodoxin FldB -
PF325_RS19740 (PF325_19740) 4042743..4043153 - 411 WP_017382887.1 protein YgfX Toxin
PF325_RS19745 (PF325_19745) 4043134..4043400 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PF325_RS19750 (PF325_19750) 4043695..4044675 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
PF325_RS19755 (PF325_19755) 4044787..4045446 - 660 WP_047050804.1 hemolysin III family protein -
PF325_RS19760 (PF325_19760) 4045713..4046444 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
PF325_RS19765 (PF325_19765) 4046561..4047994 + 1434 WP_032660252.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T267274 WP_017382887.1 NZ_CP115689:c4043153-4042743 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT267274 WP_003863437.1 NZ_CP115689:c4043400-4043134 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References