267269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2485744..2486483 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PF325_RS12295 Protein ID WP_045329830.1
Coordinates 2485744..2486229 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PF325_RS12300 Protein ID WP_003857131.1
Coordinates 2486217..2486483 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS12270 (PF325_12270) 2481127..2481885 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
PF325_RS12275 (PF325_12275) 2481990..2483282 + 1293 WP_271040259.1 glycosyl hydrolase family 28 protein -
PF325_RS12280 (PF325_12280) 2483282..2483896 + 615 WP_080338042.1 NUDIX hydrolase -
PF325_RS12285 (PF325_12285) 2484143..2485108 + 966 WP_214587177.1 hypothetical protein -
PF325_RS12290 (PF325_12290) 2485124..2485693 + 570 WP_063847895.1 hypothetical protein -
PF325_RS12295 (PF325_12295) 2485744..2486229 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
PF325_RS12300 (PF325_12300) 2486217..2486483 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PF325_RS12305 (PF325_12305) 2486547..2487476 - 930 WP_047726560.1 LysR family transcriptional regulator -
PF325_RS12310 (PF325_12310) 2487606..2488994 + 1389 WP_252051113.1 MFS transporter -
PF325_RS12315 (PF325_12315) 2489017..2490012 - 996 WP_017382342.1 DUF2891 domain-containing protein -
PF325_RS12320 (PF325_12320) 2490022..2491008 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T267269 WP_045329830.1 NZ_CP115689:c2486229-2485744 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT267269 WP_003857131.1 NZ_CP115689:c2486483-2486217 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References