267266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 971649..972328 Replicon chromosome
Accession NZ_CP115689
Organism Enterobacter hormaechei strain 2020CK-00204

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag PF325_RS04575 Protein ID WP_000854680.1
Coordinates 971649..971990 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A5C1BXL1
Locus tag PF325_RS04580 Protein ID WP_023336793.1
Coordinates 972011..972328 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF325_RS04550 (PF325_04550) 966821..967222 + 402 WP_006809999.1 sigma factor-binding protein Crl -
PF325_RS04555 (PF325_04555) 967354..968406 - 1053 WP_252051384.1 phosphoporin PhoE -
PF325_RS04560 (PF325_04560) 968712..969815 + 1104 WP_252051381.1 glutamate 5-kinase -
PF325_RS04565 (PF325_04565) 969827..971080 + 1254 WP_058689030.1 glutamate-5-semialdehyde dehydrogenase -
PF325_RS04575 (PF325_04575) 971649..971990 - 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
PF325_RS04580 (PF325_04580) 972011..972328 - 318 WP_023336793.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
PF325_RS04585 (PF325_04585) 972347..972568 - 222 WP_000691994.1 DUF987 domain-containing protein -
PF325_RS04590 (PF325_04590) 972577..973053 - 477 WP_023336794.1 RadC family protein -
PF325_RS04595 (PF325_04595) 973069..973527 - 459 WP_000211838.1 antirestriction protein -
PF325_RS04600 (PF325_04600) 973625..973864 - 240 WP_000194654.1 DUF905 family protein -
PF325_RS04605 (PF325_04605) 973941..974408 - 468 WP_001581459.1 protein YkfB -
PF325_RS04610 (PF325_04610) 974432..974875 - 444 WP_000824223.1 lipoprotein YafY -
PF325_RS04615 (PF325_04615) 974875..975111 - 237 WP_001144031.1 protein YpjK -
PF325_RS04620 (PF325_04620) 975152..975853 - 702 WP_006812588.1 WYL domain-containing protein -
PF325_RS04625 (PF325_04625) 976070..976891 - 822 WP_000197389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T267266 WP_000854680.1 NZ_CP115689:c971990-971649 [Enterobacter hormaechei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12016.63 Da        Isoelectric Point: 7.0270

>AT267266 WP_023336793.1 NZ_CP115689:c972328-972011 [Enterobacter hormaechei]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHS4

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BXL1

References