Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/FR47-DUF1778
Location 39475..40272 Replicon plasmid unnamed2
Accession NZ_CP115674
Organism Enterobacter hormaechei strain 2020CK-00203

Toxin (Protein)


Gene name KacT Uniprot ID F5S3R9
Locus tag PF324_RS23635 Protein ID WP_006812498.1
Coordinates 39748..40272 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5S3R8
Locus tag PF324_RS23630 Protein ID WP_006812497.1
Coordinates 39475..39744 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF324_RS23605 (PF324_23605) 34848..36188 - 1341 WP_006812582.1 DnaB-like helicase C-terminal domain-containing protein -
PF324_RS23610 (PF324_23610) 36249..36974 - 726 WP_006812583.1 hypothetical protein -
PF324_RS23615 (PF324_23615) 37238..38035 + 798 WP_006812584.1 DUF2971 domain-containing protein -
PF324_RS23620 (PF324_23620) 38077..38430 - 354 WP_160859104.1 hypothetical protein -
PF324_RS23625 (PF324_23625) 38436..39101 - 666 WP_023315962.1 AAA family ATPase -
PF324_RS23630 (PF324_23630) 39475..39744 + 270 WP_006812497.1 DUF1778 domain-containing protein Antitoxin
PF324_RS23635 (PF324_23635) 39748..40272 + 525 WP_006812498.1 GNAT family N-acetyltransferase Toxin
PF324_RS23640 (PF324_23640) 40299..40463 - 165 WP_006812499.1 hypothetical protein -
PF324_RS23645 (PF324_23645) 40456..40707 - 252 WP_000147960.1 hypothetical protein -
PF324_RS23650 (PF324_23650) 40709..41401 - 693 WP_006812500.1 membrane protein -
PF324_RS23655 (PF324_23655) 41415..41738 - 324 WP_000064173.1 hypothetical protein -
PF324_RS23660 (PF324_23660) 41813..42601 - 789 WP_032655902.1 receptor-recognizing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111387 111387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-149)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19356.13 Da        Isoelectric Point: 8.9844

>T267263 WP_006812498.1 NZ_CP115674:39748-40272 [Enterobacter hormaechei]
VANLTIEMFSEEAVYDFSCFDCGETSLNDFLNNRLAQQHSGRILRGYLLLTRDPIPKVMGFYTLSGSCFARNTLPSNTQQ
RKVPYSDAPSVTLGRLAIDKSIQRQGYGETLVAHAMKVVYRASLAVGIYALFVDAKNENAMRFYKQLGFTPLTGDNANSL
FYPTKGIEKLFGGK

Download         Length: 525 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10114.51 Da        Isoelectric Point: 4.8483

>AT267263 WP_006812497.1 NZ_CP115674:39475-39744 [Enterobacter hormaechei]
MSALKKQRIDLRLTDDDKSMIEEAAAMTNQTITQFMVASASERAAEVIEQHRRLILSEESWNIVMDAISNPPAPNDRLKR
AAERLQSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0QWY8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0QUA3

References